Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.
Jonsson, Malin K B
Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. [electronic resource] - Journal of molecular and cellular cardiology May 2012 - 998-1008 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1095-8584
10.1016/j.yjmcc.2012.02.002 doi
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester--pharmacology
Action Potentials
Arrhythmias, Cardiac--drug therapy
Benzazepines--pharmacology
Calcium Channel Agonists--pharmacology
Calcium Channel Blockers--pharmacology
Calcium Signaling
Cells, Cultured
Cisapride--pharmacology
Drug Evaluation, Preclinical
ERG1 Potassium Channel
Embryonic Stem Cells--physiology
Ether-A-Go-Go Potassium Channels--antagonists & inhibitors
Humans
Myocytes, Cardiac--drug effects
Nifedipine--pharmacology
Patch-Clamp Techniques
Sodium Channels--metabolism
Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. [electronic resource] - Journal of molecular and cellular cardiology May 2012 - 998-1008 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1095-8584
10.1016/j.yjmcc.2012.02.002 doi
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester--pharmacology
Action Potentials
Arrhythmias, Cardiac--drug therapy
Benzazepines--pharmacology
Calcium Channel Agonists--pharmacology
Calcium Channel Blockers--pharmacology
Calcium Signaling
Cells, Cultured
Cisapride--pharmacology
Drug Evaluation, Preclinical
ERG1 Potassium Channel
Embryonic Stem Cells--physiology
Ether-A-Go-Go Potassium Channels--antagonists & inhibitors
Humans
Myocytes, Cardiac--drug effects
Nifedipine--pharmacology
Patch-Clamp Techniques
Sodium Channels--metabolism