Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma.

Cook, Natalie

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma. [electronic resource] - The Journal of experimental medicine Mar 2012 - 437-44 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1540-9538

10.1084/jem.20111923 doi


Amyloid Precursor Protein Secretases--antagonists & inhibitors
Animals
Carcinoma, Pancreatic Ductal--blood supply
Cell Line, Tumor
Cell Proliferation--drug effects
Cyclic S-Oxides--administration & dosage
Deoxycytidine--administration & dosage
Drug Synergism
Drug Therapy, Combination
Endothelial Cells--drug effects
Humans
Hypoxia--chemically induced
Mice
Mice, Mutant Strains
Necrosis
Pancreatic Neoplasms--blood supply
Protease Inhibitors--administration & dosage
Receptors, Notch--metabolism
Signal Transduction--drug effects
Thiadiazoles--administration & dosage
Translational Research, Biomedical
Gemcitabine