5-azacitidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU.1 gene and cell differentiation capacity.

Curik, N

5-azacitidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU.1 gene and cell differentiation capacity. [electronic resource] - Leukemia Aug 2012 - 1804-11 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5551

10.1038/leu.2012.47 doi


Aged
Aged, 80 and over
Antimetabolites, Antineoplastic--pharmacology
Azacitidine--pharmacology
Cell Differentiation--drug effects
Cell Line, Tumor
Chromatin--genetics
Colony-Stimulating Factors--pharmacology
DNA Methylation--drug effects
Female
Gene Expression Regulation, Leukemic--drug effects
Humans
Male
Middle Aged
Myelodysplastic Syndromes--drug therapy
Neoplastic Stem Cells--cytology
Proto-Oncogene Proteins--genetics
Regulatory Sequences, Nucleic Acid--drug effects
Trans-Activators--genetics
Transcriptional Activation--drug effects