Synthesis and biological properties of highly sequence-specific-alkylating N-methylpyrrole-N-methylimidazole polyamide conjugates.

Kashiwazaki, Gengo

Synthesis and biological properties of highly sequence-specific-alkylating N-methylpyrrole-N-methylimidazole polyamide conjugates. [electronic resource] - Journal of medicinal chemistry Mar 2012 - 2057-66 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm201225z doi


Animals
Antineoplastic Agents, Alkylating--chemical synthesis
Cell Line, Tumor
DNA--chemistry
Drug Screening Assays, Antitumor
Electrophoresis, Polyacrylamide Gel
Gene Expression Profiling
Gene Expression Regulation
Genome, Human
Humans
Imidazoles--chemical synthesis
Indoles--chemical synthesis
Liposomes
Male
Mice
Mice, Nude
Neoplasm Transplantation
Nylons--chemical synthesis
Oligonucleotide Array Sequence Analysis
Pyrroles--chemical synthesis
Structure-Activity Relationship
Transplantation, Heterologous