Normalization of cholesterol homeostasis by 2-hydroxypropyl-β-cyclodextrin in neurons and glia from Niemann-Pick C1 (NPC1)-deficient mice.

Peake, Kyle B

Normalization of cholesterol homeostasis by 2-hydroxypropyl-β-cyclodextrin in neurons and glia from Niemann-Pick C1 (NPC1)-deficient mice. [electronic resource] - The Journal of biological chemistry Mar 2012 - 9290-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M111.326405 doi


2-Hydroxypropyl-beta-cyclodextrin
Animals
Cholesterol--metabolism
Endosomes--drug effects
Female
Humans
Intracellular Signaling Peptides and Proteins
Lysosomes--drug effects
Male
Mice
Mice, Inbred BALB C
Mice, Knockout
Neuroglia--drug effects
Neurons--drug effects
Niemann-Pick C1 Protein
Niemann-Pick Disease, Type C--genetics
Proteins--genetics
beta-Cyclodextrins--pharmacology