Human neutrophil alpha-defensins induce formation of fibrinogen and thrombospondin-1 amyloid-like structures and activate platelets via glycoprotein IIb/IIIa.

Horn, M

Human neutrophil alpha-defensins induce formation of fibrinogen and thrombospondin-1 amyloid-like structures and activate platelets via glycoprotein IIb/IIIa. [electronic resource] - Journal of thrombosis and haemostasis : JTH Apr 2012 - 647-61 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1538-7836

10.1111/j.1538-7836.2012.04640.x doi


Amyloid--metabolism
Antithrombins--pharmacology
Apoptosis
Blood Platelets--drug effects
Caspase 3--metabolism
Cell Degranulation
Enzyme-Linked Immunosorbent Assay
Fibrinogen--metabolism
Flow Cytometry
Humans
Inflammation--blood
Integrin alpha2--metabolism
Integrin beta3--metabolism
Membrane Potential, Mitochondrial
Microscopy, Confocal
Neutrophil Activation
Neutrophils--immunology
Platelet Adhesiveness
Platelet Aggregation
Platelet Aggregation Inhibitors--pharmacology
Platelet Function Tests
Platelet Glycoprotein GPIIb-IIIa Complex--antagonists & inhibitors
Serpins--pharmacology
Thrombosis--blood
Thrombospondin 1--metabolism
Time Factors
alpha-Defensins--metabolism