Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria.

Onoue, Satomi

Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria. [electronic resource] - International journal of pharmaceutics Apr 2012 - 61-66 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1873-3476

10.1016/j.ijpharm.2012.01.014 doi


Achlorhydria--chemically induced
Administration, Oral
Animals
Area Under Curve
Biological Availability
Chemistry, Pharmaceutical
Chromatography, Liquid
Crystallization
Crystallography, X-Ray
Dipyridamole--administration & dosage
Disease Models, Animal
Drug Compounding
Drug Stability
Fumarates--chemistry
Half-Life
Hydrogen-Ion Concentration
Male
Metabolic Clearance Rate
Microscopy, Electron, Scanning
Omeprazole
Phosphodiesterase Inhibitors--administration & dosage
Powder Diffraction
Rats
Rats, Sprague-Dawley
Solubility
Spectrometry, Mass, Electrospray Ionization
Technology, Pharmaceutical--methods