Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.

Zhou, Xin

Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice. [electronic resource] - The Journal of pharmacology and experimental therapeutics Apr 2012 - 233-41 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

1521-0103

10.1124/jpet.111.190173 doi


Adenocarcinoma--chemically induced
Adenocarcinoma of Lung
Animals
Aryl Hydrocarbon Hydroxylases--deficiency
Biotransformation--drug effects
Cytochrome P-450 CYP2A6
Cytochrome P450 Family 2
Female
Lung--drug effects
Lung Neoplasms--chemically induced
Mice
Mice, Knockout
Microsomes, Liver--drug effects
Nitrosamines--metabolism
Pyridines--metabolism
Tissue Distribution--drug effects