Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics.

McGillivray, Shauna M

Pharmacological inhibition of the ClpXP protease increases bacterial susceptibility to host cathelicidin antimicrobial peptides and cell envelope-active antibiotics. [electronic resource] - Antimicrobial agents and chemotherapy Apr 2012 - 1854-61 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1098-6596

10.1128/AAC.05131-11 doi


Amino Acid Sequence
Anti-Bacterial Agents--pharmacology
Antimicrobial Cationic Peptides--pharmacology
Bacillus anthracis--drug effects
Bacteria--drug effects
Cell Membrane--metabolism
Drug Resistance, Bacterial
Drug Synergism
Endopeptidase Clp--antagonists & inhibitors
Escherichia coli Proteins--antagonists & inhibitors
Methicillin-Resistant Staphylococcus aureus--drug effects
Molecular Sequence Data
Protease Inhibitors--pharmacology
Staphylococcus aureus--drug effects
Tetrazoles--pharmacology
Cathelicidins