Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88.

Kato, Kosuke

Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Feb 2012 - 2014-22 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1550-6606

10.4049/jimmunol.1102405 doi


Animals
Cell Line
Epithelial Cells--metabolism
ErbB Receptors--biosynthesis
Flagellin--metabolism
Gene Expression Regulation
HEK293 Cells
Humans
Interleukin-8--biosynthesis
Lung--metabolism
Lung Diseases--immunology
Mice
Mice, Inbred C57BL
Mitogen-Activated Protein Kinases--biosynthesis
Mucin-1--biosynthesis
Myeloid Differentiation Factor 88--biosynthesis
NF-kappa B--biosynthesis
Phosphorylation
Pseudomonas Infections--immunology
Pseudomonas aeruginosa--immunology
Respiratory Mucosa--metabolism
Signal Transduction
Toll-Like Receptor 5--metabolism
Tumor Necrosis Factor-alpha--metabolism