Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations.

Xu, Yechun

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations. [electronic resource] - Acta crystallographica. Section D, Biological crystallography Jan 2012 - 13-25 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1399-0047

10.1107/S0907444911047251 doi


Amyloid Precursor Protein Secretases--chemistry
Aspartic Acid Endopeptidases--chemistry
Catalytic Domain
Crystallography, X-Ray
Humans
Hydrogen Bonding
Ligands
Models, Molecular
Molecular Dynamics Simulation
Protein Structure, Quaternary