Discovery of bacterial NAD⁺-dependent DNA ligase inhibitors: improvements in clearance of adenosine series.

Stokes, Suzanne S

Discovery of bacterial NAD⁺-dependent DNA ligase inhibitors: improvements in clearance of adenosine series. [electronic resource] - Bioorganic & medicinal chemistry letters Jan 2012 - 85-9 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2011.11.071 doi


Adenine--chemistry
Adenosine--chemistry
Administration, Oral
Animals
Anti-Bacterial Agents--chemical synthesis
Biological Availability
Chromatography, Liquid--methods
DNA Ligases--antagonists & inhibitors
Dogs
Drug Design
Drug Evaluation, Preclinical--methods
Enzyme Inhibitors--pharmacology
Fluorine--chemistry
Inhibitory Concentration 50
Mass Spectrometry--methods
Models, Chemical
NAD--chemistry
Rats