Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.
Koole, Cassandra
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function. [electronic resource] - The Journal of biological chemistry Feb 2012 - 3659-73 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1083-351X
10.1074/jbc.M111.309369 doi
Allosteric Regulation
Amino Acid Substitution
Biomimetic Materials--chemistry
Cell Line
Glucagon-Like Peptide-1 Receptor
Humans
MAP Kinase Signaling System--drug effects
Mitogen-Activated Protein Kinase 1--chemistry
Mitogen-Activated Protein Kinase 3--chemistry
Mutation, Missense
Peptides--chemistry
Protein Structure, Secondary
Protein Structure, Tertiary
Receptors, Glucagon--chemistry
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function. [electronic resource] - The Journal of biological chemistry Feb 2012 - 3659-73 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1083-351X
10.1074/jbc.M111.309369 doi
Allosteric Regulation
Amino Acid Substitution
Biomimetic Materials--chemistry
Cell Line
Glucagon-Like Peptide-1 Receptor
Humans
MAP Kinase Signaling System--drug effects
Mitogen-Activated Protein Kinase 1--chemistry
Mitogen-Activated Protein Kinase 3--chemistry
Mutation, Missense
Peptides--chemistry
Protein Structure, Secondary
Protein Structure, Tertiary
Receptors, Glucagon--chemistry