BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.
Faber, Anthony C
BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. [electronic resource] - Cancer discovery Sep 2011 - 352-65 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2159-8290
10.1158/2159-8290.CD-11-0106 doi
Animals
Apoptosis--drug effects
Apoptosis Regulatory Proteins--biosynthesis
BH3 Interacting Domain Death Agonist Protein--genetics
Bcl-2-Like Protein 11
Cell Line, Tumor
Cohort Studies
ErbB Receptors--antagonists & inhibitors
Female
Humans
Lung Neoplasms--drug therapy
Membrane Proteins--biosynthesis
Mice
Mice, Nude
Oncogenes
Phosphatidylinositol 3-Kinases--genetics
Phosphoinositide-3 Kinase Inhibitors
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins--biosynthesis
Receptor, ErbB-2--antagonists & inhibitors
Retrospective Studies
Signal Transduction--drug effects
BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors. [electronic resource] - Cancer discovery Sep 2011 - 352-65 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2159-8290
10.1158/2159-8290.CD-11-0106 doi
Animals
Apoptosis--drug effects
Apoptosis Regulatory Proteins--biosynthesis
BH3 Interacting Domain Death Agonist Protein--genetics
Bcl-2-Like Protein 11
Cell Line, Tumor
Cohort Studies
ErbB Receptors--antagonists & inhibitors
Female
Humans
Lung Neoplasms--drug therapy
Membrane Proteins--biosynthesis
Mice
Mice, Nude
Oncogenes
Phosphatidylinositol 3-Kinases--genetics
Phosphoinositide-3 Kinase Inhibitors
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins--biosynthesis
Receptor, ErbB-2--antagonists & inhibitors
Retrospective Studies
Signal Transduction--drug effects