Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties.

Portoghese, P S

Synthesis and pharmacologic characterization of an alkylating analogue (chlornaltrexamine) of naltrexone with ultralong-lasting narcotic antagonist properties. [electronic resource] - Journal of medicinal chemistry Feb 1979 - 168-73 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0022-2623

10.1021/jm00188a008 doi


Alkylating Agents--chemical synthesis
Analgesics
Animals
Humans
In Vitro Techniques
Male
Mice
Molecular Conformation
Morphine--antagonists & inhibitors
Morphine Dependence--prevention & control
Naloxone--analogs & derivatives
Naltrexone--analogs & derivatives
Narcotic Antagonists--chemical synthesis
Nitrogen Mustard Compounds--chemical synthesis
Rats
Receptors, Opioid--metabolism
Time Factors