Validated LC-MS/MS method for the quantitative determination of the glucosylceramide synthase inhibitor miglustat in mouse plasma and human plasma and its application to a pharmacokinetic study.

Spieker, Elke

Validated LC-MS/MS method for the quantitative determination of the glucosylceramide synthase inhibitor miglustat in mouse plasma and human plasma and its application to a pharmacokinetic study. [electronic resource] - Journal of pharmaceutical and biomedical analysis Feb 2012 - 123-9 p. digital

Publication Type: Journal Article

1873-264X

10.1016/j.jpba.2011.10.016 doi


1-Deoxynojirimycin--analogs & derivatives
Animals
Calibration
Chromatography, High Pressure Liquid--instrumentation
Drug Stability
Enzyme Inhibitors--blood
Glucosyltransferases--antagonists & inhibitors
Humans
Limit of Detection
Mice
Reference Standards
Reproducibility of Results
Species Specificity
Tandem Mass Spectrometry--instrumentation