In silico engineering of L-asparaginase to have reduced glutaminase side activity for effective treatment of acute lymphoblastic leukemia.
Ln, Ramya
In silico engineering of L-asparaginase to have reduced glutaminase side activity for effective treatment of acute lymphoblastic leukemia. [electronic resource] - Journal of pediatric hematology/oncology Dec 2011 - 617-21 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1536-3678
10.1097/MPH.0b013e31822aa4ec doi
Asparaginase--chemistry
Asparagine--chemistry
Catalytic Domain
Child
Computer Simulation
Drug Design
Glutaminase--chemistry
Glutamine--chemistry
Humans
Ligands
Mutagenesis, Site-Directed
Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy
Protein Engineering--methods
In silico engineering of L-asparaginase to have reduced glutaminase side activity for effective treatment of acute lymphoblastic leukemia. [electronic resource] - Journal of pediatric hematology/oncology Dec 2011 - 617-21 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1536-3678
10.1097/MPH.0b013e31822aa4ec doi
Asparaginase--chemistry
Asparagine--chemistry
Catalytic Domain
Child
Computer Simulation
Drug Design
Glutaminase--chemistry
Glutamine--chemistry
Humans
Ligands
Mutagenesis, Site-Directed
Precursor Cell Lymphoblastic Leukemia-Lymphoma--drug therapy
Protein Engineering--methods