A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicity.

Cheng, Hui

A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicity. [electronic resource] - Circulation research Dec 2011 - 1401-9 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1524-4571

10.1161/CIRCRESAHA.111.255695 doi


Animals
Animals, Genetically Modified
Apoptosis--drug effects
Benzenesulfonates--pharmacology
Cardiotoxins--pharmacology
Cell Survival--drug effects
Cells, Cultured
Extracellular Signal-Regulated MAP Kinases--antagonists & inhibitors
Female
Gefitinib
Indoles--pharmacology
Male
Models, Animal
Myocytes, Cardiac--cytology
Niacinamide--analogs & derivatives
Phenylurea Compounds
Protein Kinase Inhibitors--pharmacology
Proto-Oncogene Proteins B-raf--antagonists & inhibitors
Proto-Oncogene Proteins c-raf--antagonists & inhibitors
Pyridines--pharmacology
Pyrroles--pharmacology
Quinazolines--pharmacology
Rats
Rats, Sprague-Dawley
Signal Transduction--drug effects
Sorafenib
Sunitinib
Zebrafish