Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not.

Mietens, Andrea

Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not. [electronic resource] - Molecular and cellular endocrinology Feb 2012 - 145-53 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1872-8057

10.1016/j.mce.2011.09.039 doi


Adult
Aged
Aged, 80 and over
Animals
Atrial Natriuretic Factor--pharmacology
Cyclic GMP--metabolism
Cyclic Nucleotide Phosphodiesterases, Type 5--genetics
Epididymis--drug effects
Humans
Hypertension, Pulmonary--drug therapy
Male
Middle Aged
Muscle Contraction--drug effects
Muscle, Smooth--drug effects
Nitric Oxide--metabolism
Nitric Oxide Donors--pharmacology
Nitroprusside--pharmacology
Organ Culture Techniques
Phosphodiesterase 5 Inhibitors--adverse effects
Piperazines--adverse effects
Purines--adverse effects
RNA, Messenger--metabolism
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Sildenafil Citrate
Sulfones--adverse effects