Ligand-independent transforming growth factor-β type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition.

DeMaio, Lucas

Ligand-independent transforming growth factor-β type I receptor signalling mediates type I collagen-induced epithelial-mesenchymal transition. [electronic resource] - The Journal of pathology Mar 2012 - 633-44 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1096-9896

10.1002/path.3016 doi


Actins--metabolism
Alveolar Epithelial Cells--drug effects
Angiotensin II--metabolism
Animals
Antibiotics, Antineoplastic--toxicity
Benzamides--pharmacology
Bleomycin--toxicity
Cells, Cultured
Collagen Type I--pharmacology
Dioxoles--pharmacology
Disease Models, Animal
Epithelial-Mesenchymal Transition--drug effects
Female
Ligands
Male
Mice
Mice, Knockout
Protein Serine-Threonine Kinases--antagonists & inhibitors
Pulmonary Fibrosis--chemically induced
Receptor, Transforming Growth Factor-beta Type I
Receptors, Transforming Growth Factor beta--antagonists & inhibitors
Signal Transduction
Vimentin--metabolism