Pharmacokinetics of TH-302: a hypoxically activated prodrug of bromo-isophosphoramide mustard in mice, rats, dogs and monkeys.

Jung, Donald

Pharmacokinetics of TH-302: a hypoxically activated prodrug of bromo-isophosphoramide mustard in mice, rats, dogs and monkeys. [electronic resource] - Cancer chemotherapy and pharmacology Mar 2012 - 643-54 p. digital

Publication Type: Journal Article

1432-0843

10.1007/s00280-011-1741-6 doi


Administration, Oral
Animals
Dogs
Drug Evaluation, Preclinical
Female
Half-Life
Humans
Hypoxia--metabolism
Infusions, Intravenous
Injections, Intraperitoneal
Injections, Intravenous
Macaca fascicularis
Male
Mice
Mice, Inbred Strains
Mice, Nude
Molecular Structure
Nitroimidazoles--administration & dosage
Phosphoramide Mustards--administration & dosage
Predictive Value of Tests
Prodrugs--administration & dosage
Rats
Rats, Sprague-Dawley
Species Specificity
Tissue Distribution