Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer.

Mitch, Charles H

Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer. [electronic resource] - Journal of medicinal chemistry Dec 2011 - 8000-12 p. digital

Publication Type: Journal Article

1520-4804

10.1021/jm200789r doi


Animals
Benzamides--chemical synthesis
Brain--metabolism
CHO Cells
Chromatography, Liquid
Cricetinae
Cricetulus
HEK293 Cells
Humans
Pyrrolidines--chemical synthesis
Radioligand Assay
Rats
Receptors, Opioid, kappa--antagonists & inhibitors
Stereoisomerism
Structure-Activity Relationship
Tandem Mass Spectrometry