Chronic sympathetic activation promotes downregulation of β-adrenoceptor-mediated effects in the guinea pig heart independently of structural remodeling and systolic dysfunction.

Soltysinska, Ewa

Chronic sympathetic activation promotes downregulation of β-adrenoceptor-mediated effects in the guinea pig heart independently of structural remodeling and systolic dysfunction. [electronic resource] - Pflugers Archiv : European journal of physiology Oct 2011 - 529-43 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1432-2013

10.1007/s00424-011-1005-7 doi


Adrenergic beta-Agonists--pharmacology
Animals
Calcium Channels, L-Type--metabolism
Colforsin--pharmacology
Cyclic AMP--metabolism
Down-Regulation--drug effects
G-Protein-Coupled Receptor Kinase 2--biosynthesis
GTP-Binding Protein alpha Subunits, Gs--biosynthesis
Guinea Pigs
Isoproterenol--pharmacology
KCNQ1 Potassium Channel--metabolism
Male
Myocardial Contraction--drug effects
Myocardium--metabolism
Receptors, Adrenergic, beta--drug effects
Refractory Period, Electrophysiological
Signal Transduction--drug effects
Systole--drug effects
Ventricular Remodeling--drug effects