Intrathecal tripeptidyl-peptidase 1 reduces lysosomal storage in a canine model of late infantile neuronal ceroid lipofuscinosis.

Vuillemenot, Brian R

Intrathecal tripeptidyl-peptidase 1 reduces lysosomal storage in a canine model of late infantile neuronal ceroid lipofuscinosis. [electronic resource] - Molecular genetics and metabolism Nov 2011 - 325-37 p. digital

Publication Type: Journal Article

1096-7206

10.1016/j.ymgme.2011.06.018 doi


Aminopeptidases--administration & dosage
Animals
CHO Cells
Central Nervous System--metabolism
Chromatography, Gel
Chromatography, Ion Exchange
Cricetinae
Cricetulus
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases--administration & dosage
Dogs
Electrophysiology
Fluorescence
Gene Knockout Techniques
Humans
Immunoassay
Immunoglobulin E--blood
Injections, Spinal
Lysosomes--metabolism
Magnetic Resonance Imaging
Maze Learning--drug effects
Neuronal Ceroid-Lipofuscinoses--drug therapy
Recombinant Proteins--pharmacology
Serine Proteases--administration & dosage
Tripeptidyl-Peptidase 1