Design, synthesis, and pharmacological evaluation of novel hybrid compounds to treat sickle cell disease symptoms.

dos Santos, Jean Leandro

Design, synthesis, and pharmacological evaluation of novel hybrid compounds to treat sickle cell disease symptoms. [electronic resource] - Journal of medicinal chemistry Aug 2011 - 5811-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm200531f doi


Acetic Acid
Analgesics--chemical synthesis
Anemia, Sickle Cell--drug therapy
Animals
Anti-Inflammatory Agents--chemical synthesis
Antisickling Agents--chemical synthesis
Capsaicin
Colic--chemically induced
Drug Design
Ear--pathology
Edema--chemically induced
Female
Male
Mice
Mice, Transgenic
Models, Chemical
Molecular Structure
Peritonitis--chemically induced
Thalidomide--chemical synthesis
Thioglycolates
Tumor Necrosis Factor-alpha--metabolism