Glycogen synthase kinase-3beta (GSK3beta) negatively regulates PTTG1/human securin protein stability, and GSK3beta inactivation correlates with securin accumulation in breast tumors.

Mora-Santos, Mar

Glycogen synthase kinase-3beta (GSK3beta) negatively regulates PTTG1/human securin protein stability, and GSK3beta inactivation correlates with securin accumulation in breast tumors. [electronic resource] - The Journal of biological chemistry Aug 2011 - 30047-56 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1083-351X

10.1074/jbc.M111.232330 doi


Animals
Breast Neoplasms--genetics
COS Cells
Chlorocebus aethiops
Female
Glycogen Synthase Kinase 3--genetics
Glycogen Synthase Kinase 3 beta
HeLa Cells
Humans
Mitosis
Neoplasm Proteins--genetics
Phosphorylation
Protein Stability
SKP Cullin F-Box Protein Ligases--genetics
Securin