Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits.
Willis, Melanie Neely
Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits. [electronic resource] - Biochemistry Jul 2011 - 6508-17 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1520-4995
10.1021/bi200708w doi
Animals
Catalytic Domain
Enzyme Stability
Glutamate-Cysteine Ligase--chemistry
Glutathione--biosynthesis
Homozygote
Humans
Kinetics
Mice
Models, Biological
Mutant Proteins--metabolism
Mutation--genetics
Protein Binding
Protein Structure, Secondary
Recombinant Proteins--metabolism
Saccharomyces cerevisiae--metabolism
Structural Homology, Protein
Temperature
Enzymatic defects underlying hereditary glutamate cysteine ligase deficiency are mitigated by association of the catalytic and regulatory subunits. [electronic resource] - Biochemistry Jul 2011 - 6508-17 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1520-4995
10.1021/bi200708w doi
Animals
Catalytic Domain
Enzyme Stability
Glutamate-Cysteine Ligase--chemistry
Glutathione--biosynthesis
Homozygote
Humans
Kinetics
Mice
Models, Biological
Mutant Proteins--metabolism
Mutation--genetics
Protein Binding
Protein Structure, Secondary
Recombinant Proteins--metabolism
Saccharomyces cerevisiae--metabolism
Structural Homology, Protein
Temperature