Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts.

Copaja, Miguel

Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts. [electronic resource] - Toxicology and applied pharmacology Aug 2011 - 57-64 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1096-0333

10.1016/j.taap.2011.05.016 doi


Animals
Apoptosis--drug effects
Benzamides--pharmacology
Caspases--physiology
Cell Survival--drug effects
Cells, Cultured
Cholesterol--biosynthesis
Fibroblasts--drug effects
Heart--drug effects
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Methionine--analogs & derivatives
Myofibroblasts--drug effects
Rats
Rats, Sprague-Dawley
Simvastatin--pharmacology
rhoA GTP-Binding Protein--physiology