The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents.

Hutson, P H

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents. [electronic resource] - Neuropharmacology Sep 2011 - 665-76 p. digital

Publication Type: Comparative Study; Journal Article

1873-7064

10.1016/j.neuropharm.2011.05.009 doi


3',5'-Cyclic-AMP Phosphodiesterases--antagonists & inhibitors
Animals
CHO Cells
Cognition--drug effects
Cricetinae
Cricetulus
Dose-Response Relationship, Drug
Female
HEK293 Cells
Hippocampus--drug effects
Humans
Macaca mulatta
Male
Mice
Mice, Inbred C57BL
Mice, Inbred ICR
Neuronal Plasticity--drug effects
Phosphodiesterase Inhibitors--metabolism
Pyrazoles--metabolism
Pyrimidinones--metabolism
Rats
Rats, Sprague-Dawley
Rats, Wistar
Synapses--drug effects