Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors.

Lovly, Christine M

Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors. [electronic resource] - Cancer research Jul 2011 - 4920-31 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1538-7445

10.1158/0008-5472.CAN-10-3879 doi


Anaplastic Lymphoma Kinase
Animals
Brain--metabolism
Cell Line, Tumor
Drug Synergism
Female
Humans
Isoenzymes
Male
Mice
Mice, Inbred C57BL
Mice, Nude
Models, Molecular
Neoplasms--drug therapy
Point Mutation
Protein Kinase Inhibitors--chemistry
Pyridazines--chemistry
Receptor Protein-Tyrosine Kinases--antagonists & inhibitors
Sirolimus--pharmacology
TOR Serine-Threonine Kinases--antagonists & inhibitors