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Huehls, Amelia M

Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells. [electronic resource] - Cancer research Jul 2011 - 4944-54 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

ISSN: 1538-7445

Standard No.: 10.1158/0008-5472.CAN-11-0814 doi

Subjects--Topical Terms:
Antimetabolites, Antineoplastic--pharmacology
Apoptosis--drug effects
Ataxia Telangiectasia Mutated Proteins
Benzimidazoles--pharmacology
Cell Cycle--drug effects
Cell Cycle Proteins--metabolism
Cell Line, Tumor
Checkpoint Kinase 1
Checkpoint Kinase 2
DNA Repair
DNA-Binding Proteins--deficiency
Drug Synergism
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
Female
Floxuridine--pharmacology
Fluorouracil--pharmacology
Humans
Ovarian Neoplasms--drug therapy
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerase Inhibitors
Poly(ADP-ribose) Polymerases--metabolism
Protein Kinases--metabolism
Protein Serine-Threonine Kinases--metabolism
RNA, Small Interfering--administration & dosage
Transfection
Tumor Suppressor Proteins--metabolism
X-ray Repair Cross Complementing Protein 1