Effect of linagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers.

Graefe-Mody, E U

Effect of linagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. [electronic resource] - International journal of clinical pharmacology and therapeutics May 2011 - 300-10 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0946-1965

10.5414/cp201507 doi


Adult
Anticoagulants--pharmacokinetics
Area Under Curve
Aryl Hydrocarbon Hydroxylases--genetics
Biological Availability
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2C9
Dipeptidyl-Peptidase IV Inhibitors--adverse effects
Dose-Response Relationship, Drug
Drug Interactions
Half-Life
Humans
International Normalized Ratio
Linagliptin
Male
Middle Aged
Prothrombin Time
Purines--adverse effects
Quinazolines--adverse effects
Software
Stereoisomerism
Tandem Mass Spectrometry
Warfarin--pharmacokinetics
Young Adult