Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.

Mandal, Pijus K

Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. [electronic resource] - Journal of medicinal chemistry May 2011 - 3549-63 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm2000882 doi


Active Transport, Cell Nucleus
Antineoplastic Agents--pharmacology
Cell Line, Tumor
Chemistry, Pharmaceutical--methods
Drug Design
Drug Screening Assays, Antitumor
Humans
Kinetics
Models, Chemical
Phosphatidylinositol 3-Kinases--metabolism
Phosphorylation
Prodrugs
Protein Structure, Tertiary
STAT3 Transcription Factor--chemistry
Signal Transduction
src Homology Domains