Synthesis and structure-activity relationship of tricyclic carboxylic acids as novel anti-histamines.

Kubota, Katsumi

Synthesis and structure-activity relationship of tricyclic carboxylic acids as novel anti-histamines. [electronic resource] - Bioorganic & medicinal chemistry May 2011 - 3005-21 p. digital

Publication Type: Journal Article

1464-3391

10.1016/j.bmc.2011.03.003 doi


Animals
Anti-Inflammatory Agents--chemical synthesis
Azepines--chemical synthesis
Caco-2 Cells
Carboxylic Acids--chemical synthesis
Cell Membrane Permeability
Cyclization
Histamine H1 Antagonists--chemical synthesis
Humans
Mice
Oxazepines--chemical synthesis
Protein Binding
Pyrimidines--chemical synthesis
Rats
Receptors, Histamine H1--chemistry
Structure-Activity Relationship