Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).

Day, Jonathan P

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). [electronic resource] - Journal of medicinal chemistry May 2011 - 3331-47 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1520-4804

10.1021/jm200070e doi


Adaptor Proteins, Signal Transducing--physiology
Animals
CHO Cells
Catalytic Domain
Cricetinae
Cricetulus
Crystallography, X-Ray
Cyclic Nucleotide Phosphodiesterases, Type 4--chemistry
Isoenzymes--antagonists & inhibitors
Models, Molecular
Phosphodiesterase 4 Inhibitors--chemistry
Pyridines--chemistry
Rolipram--chemistry
Sequestosome-1 Protein
Spiro Compounds--chemistry
Stereoisomerism
Structure-Activity Relationship
Xanthines--chemistry