2-methoxyestradiol analogue ENMD-1198 reduces breast cancer-induced osteolysis and tumor burden both in vitro and in vivo.

Snoeks, Thomas J A

2-methoxyestradiol analogue ENMD-1198 reduces breast cancer-induced osteolysis and tumor burden both in vitro and in vivo. [electronic resource] - Molecular cancer therapeutics May 2011 - 874-82 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1538-8514

10.1158/1535-7163.MCT-10-0997 doi


Animals
Antineoplastic Agents--pharmacology
Bone Neoplasms--pathology
Bone Resorption--drug therapy
Breast Neoplasms--drug therapy
Cell Line, Tumor
Cell Proliferation--drug effects
Cell Survival--drug effects
Estrenes--pharmacology
Female
Humans
Mice
Mice, Inbred BALB C
Mice, Nude
Neovascularization, Pathologic--drug therapy
Osteoclasts--drug effects
Osteolysis--drug therapy
Pregnancy
Tumor Burden--drug effects