Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression.

Elis, Sebastien

Increased serum IGF-1 levels protect the musculoskeletal system but are associated with elevated oxidative stress markers and increased mortality independent of tissue igf1 gene expression. [electronic resource] - Aging cell Jun 2011 - 547-50 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1474-9726

10.1111/j.1474-9726.2011.00683.x doi


Aging
Animals
Bone Development--genetics
Female
Gene Expression
Insulin-Like Growth Factor I--genetics
Isoprostanes--analysis
Lipid Peroxidation
Liver--metabolism
Liver Neoplasms--genetics
Longevity
Male
Mice
Mice, Transgenic
Models, Animal
Musculoskeletal System--metabolism
Oxidative Stress
Sex Factors
Stomach Neoplasms--genetics