The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis.

Procopiou, Panayiotis A

The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis. [electronic resource] - Journal of medicinal chemistry Apr 2011 - 2183-95 p. digital

Publication Type: Journal Article

1520-4804

10.1021/jm1013874 doi


Administration, Intranasal
Administration, Oral
Drug Discovery--methods
Histamine H1 Antagonists--administration & dosage
Histamine H3 Antagonists--administration & dosage
Humans
Models, Molecular
Phthalazines--administration & dosage
Protein Conformation
Receptors, Histamine H1--chemistry
Receptors, Histamine H3--metabolism
Rhinitis--drug therapy