The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88.

Puneet, Padmam

The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88. [electronic resource] - Nature immunology Apr 2011 - 344-51 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication

1529-2916

10.1038/ni.2004 doi


Animals
Autophagy--drug effects
Cells, Cultured
Female
Helminth Proteins--pharmacology
Humans
Immunoblotting
Inflammation Mediators--immunology
Macrophages--drug effects
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Microscopy, Confocal
Microscopy, Electron
Myeloid Differentiation Factor 88--immunology
Phagosomes--drug effects
Shock, Septic--genetics
Signal Transduction--drug effects
Toll-Like Receptor 2--immunology
Toll-Like Receptor 4--genetics