The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling.

Gildea, Derek E

The pleiotropic mouse phenotype extra-toes spotting is caused by translation initiation factor Eif3c mutations and is associated with disrupted sonic hedgehog signaling. [electronic resource] - FASEB journal : official publication of the Federation of American Societies for Experimental Biology May 2011 - 1596-605 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Intramural

1530-6860

10.1096/fj.10-169771 doi


Animals
Blotting, Western
Eukaryotic Initiation Factor-3--genetics
Genotype
Hedgehog Proteins--genetics
In Situ Hybridization
Kruppel-Like Transcription Factors--genetics
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mutation
Nerve Tissue Proteins--genetics
Patched Receptors
Patched-1 Receptor
Phenotype
Polydactyly--genetics
Polymorphism, Genetic
Receptors, Cell Surface--genetics
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction--genetics
Zinc Finger Protein Gli3