The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo.

Nguyen, Ho-Ngoc

The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo. [electronic resource] - Biomaterials Apr 2011 - 2673-82 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1878-5905

10.1016/j.biomaterials.2010.12.044 doi


Administration, Oral
Animals
Blood Glucose--drug effects
Drug Delivery Systems--methods
Electric Impedance
Epithelial Cells--drug effects
Exenatide
Freeze Drying
Hydrogen-Ion Concentration--drug effects
Injections, Subcutaneous
Insulin--metabolism
Insulin Secretion
Male
Molecular Dynamics Simulation
Nanoparticles--chemistry
Particle Size
Peptides--administration & dosage
Pharmaceutical Vehicles--chemistry
Rats
Rats, Wistar
Solubility--drug effects
Static Electricity
Tablets, Enteric-Coated--pharmacology
Time Factors
Tissue Distribution--drug effects
Tomography, Emission-Computed, Single-Photon
Tomography, X-Ray Computed
Venoms--administration & dosage
Whole Body Imaging