Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire.

Rudd, Brian D

Evolution of the antigen-specific CD8+ TCR repertoire across the life span: evidence for clonal homogenization of the old TCR repertoire. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Feb 2011 - 2056-2064 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1550-6606

10.4049/jimmunol.1003013 doi


Animals
Animals, Newborn
CD8-Positive T-Lymphocytes--immunology
Cellular Senescence--genetics
Clone Cells
Epitopes, T-Lymphocyte--genetics
Evolution, Molecular
Herpesvirus 1, Human--immunology
Immunodominant Epitopes--genetics
Immunoglobulin Variable Region--biosynthesis
Longevity--genetics
Male
Mice
Mice, Inbred C57BL
Peptide Fragments--biosynthesis
Receptors, Antigen, T-Cell, alpha-beta--biosynthesis
Vaccinia virus--genetics
Viral Envelope Proteins--biosynthesis