New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones.

Trabanco, Andrés A

New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones. [electronic resource] - Bioorganic & medicinal chemistry letters Feb 2011 - 971-6 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2010.12.048 doi


Allosteric Regulation
High-Throughput Screening Assays
Humans
Microsomes, Liver--metabolism
Pyridines--chemical synthesis
Quinolones--chemical synthesis
Receptors, Metabotropic Glutamate--chemistry
Structure-Activity Relationship