How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics.

Costa, Mauricio G S

How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics. [electronic resource] - BMC genomics Dec 2010 - S5 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1471-2164

10.1186/1471-2164-11-S5-S5 doi


Allosteric Regulation--genetics
Binding Sites--genetics
Cathepsin B--chemistry
Enzyme Stability
Heparin--metabolism
Hydrogen-Ion Concentration
Models, Molecular
Molecular Dynamics Simulation
Static Electricity