6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty.
Portoghese, P S
6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty. [electronic resource] - Journal of medicinal chemistry Jul 1978 - 598-9 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
0022-2623
10.1021/jm00205a002 doi
Alkylating Agents--chemical synthesis
Analgesia
Binding, Competitive
Morphine--antagonists & inhibitors
Naloxone--analogs & derivatives
Naltrexone--analogs & derivatives
Narcotic Antagonists--chemical synthesis
Nitrogen Mustard Compounds--chemical synthesis
Receptors, Opioid--drug effects
6beta-[N,N-Bis(2-chloroethyl)amino]-17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxymorphinan(chlornaltrexamine) a potent opioid receptor alkylating agent with ultralong narcotic antagonist actitivty. [electronic resource] - Journal of medicinal chemistry Jul 1978 - 598-9 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
0022-2623
10.1021/jm00205a002 doi
Alkylating Agents--chemical synthesis
Analgesia
Binding, Competitive
Morphine--antagonists & inhibitors
Naloxone--analogs & derivatives
Naltrexone--analogs & derivatives
Narcotic Antagonists--chemical synthesis
Nitrogen Mustard Compounds--chemical synthesis
Receptors, Opioid--drug effects