AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradation.

Vartanian, Raffi

AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradation. [electronic resource] - Molecular cancer research : MCR Jan 2011 - 115-30 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1557-3125

10.1158/1541-7786.MCR-10-0105 doi


Animals
Antibiotics, Antineoplastic--pharmacology
Cell Line
Cell Line, Tumor
Cells, Cultured
Cyclin D1--genetics
Gene Expression--drug effects
Humans
Immunoblotting
Mice
Mice, Knockout
Models, Genetic
PTEN Phosphohydrolase--genetics
Promoter Regions, Genetic--genetics
Protein Binding--drug effects
Proto-Oncogene Proteins c-akt--genetics
Proto-Oncogene Proteins c-jun--genetics
Proto-Oncogene Proteins c-myc--genetics
RNA Interference
Repressor Proteins--genetics
Reverse Transcriptase Polymerase Chain Reaction
Sirolimus--pharmacology
TOR Serine-Threonine Kinases--antagonists & inhibitors
Transcription Factor AP-1--genetics
Ubiquitin-Protein Ligases--genetics