Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.

Hoffstrom, Benjamin G

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. [electronic resource] - Nature chemical biology Dec 2010 - 900-6 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1552-4469

10.1038/nchembio.467 doi


Affinity Labels
Alzheimer Disease--metabolism
Amyloid beta-Peptides--metabolism
Amyloid beta-Protein Precursor--metabolism
Animals
Apoptosis--drug effects
Brain--pathology
Disulfides--metabolism
Endoplasmic Reticulum--enzymology
Enzyme Inhibitors--pharmacology
Exons--genetics
Humans
Huntingtin Protein
Huntington Disease--metabolism
Molecular Chaperones--physiology
Nerve Tissue Proteins--chemistry
Nuclear Proteins--chemistry
PC12 Cells
Protein Disulfide-Isomerases--antagonists & inhibitors
Protein Folding
Proteostasis Deficiencies--pathology
Rats
Signal Transduction--physiology
Small Molecule Libraries