Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B.

Rommelaere, Guillaume

Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B. [electronic resource] - American journal of physiology. Cell physiology May 2011 - C1090-106 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1522-1563

10.1152/ajpcell.00037.2010 doi


Apoptosis--genetics
Caspase 3--metabolism
Cathepsin B--antagonists & inhibitors
Cell Line, Tumor
Cytochromes c--metabolism
DNA Fragmentation
DNA, Mitochondrial--genetics
Dipeptides--pharmacology
Down-Regulation
Enzyme Inhibitors--pharmacology
Humans
Myeloid Cell Leukemia Sequence 1 Protein
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerases--metabolism
Proto-Oncogene Proteins c-bcl-2--genetics
Staurosporine--pharmacology
bcl-X Protein--metabolism