Intrathecal orexin A increases sympathetic outflow and respiratory drive, enhances baroreflex sensitivity and blocks the somato-sympathetic reflex.

Shahid, I Z

Intrathecal orexin A increases sympathetic outflow and respiratory drive, enhances baroreflex sensitivity and blocks the somato-sympathetic reflex. [electronic resource] - British journal of pharmacology Feb 2011 - 961-73 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1476-5381

10.1111/j.1476-5381.2010.01102.x doi


Anesthesia, Spinal
Animals
Baroreflex--drug effects
Benzoxazoles--pharmacology
Evoked Potentials, Somatosensory--drug effects
Injections, Spinal
Intracellular Signaling Peptides and Proteins--administration & dosage
Kinetics
Male
Naphthyridines
Neurons--drug effects
Neuropeptides--administration & dosage
Orexin Receptors
Orexins
Peripheral Nervous System--drug effects
Phrenic Nerve--drug effects
Rats
Rats, Sprague-Dawley
Receptors, G-Protein-Coupled--antagonists & inhibitors
Receptors, Neuropeptide--antagonists & inhibitors
Respiration--drug effects
Splanchnic Nerves--drug effects
Sympathetic Nervous System--drug effects
Tachycardia--chemically induced
Urea--analogs & derivatives
Vagotomy