siRNA knockdown of ribonucleotide reductase inhibits melanoma cell line proliferation alone or synergistically with temozolomide.

Zuckerman, Jonathan E

siRNA knockdown of ribonucleotide reductase inhibits melanoma cell line proliferation alone or synergistically with temozolomide. [electronic resource] - The Journal of investigative dermatology Feb 2011 - 453-60 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1523-1747

10.1038/jid.2010.310 doi


Antineoplastic Agents, Alkylating--pharmacology
Cell Cycle--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Dacarbazine--analogs & derivatives
G1 Phase--drug effects
Gene Silencing--drug effects
Humans
Melanoma--metabolism
RNA, Small Interfering--pharmacology
Ribonucleoside Diphosphate Reductase--genetics
S Phase--drug effects
Skin Neoplasms--metabolism
Temozolomide